| dc.contributor.author | Guio, H. | |
| dc.contributor.author | Poterico, J.A. | |
| dc.contributor.author | Levano, K.S. | |
| dc.contributor.author | Cornejo-Olivas, M. | |
| dc.contributor.author | Mazzetti, P. | |
| dc.contributor.author | Manassero-Morales, G. | |
| dc.contributor.author | Ugarte-Gil, M.F. | |
| dc.contributor.author | Acevedo-Vásquez, E. | |
| dc.contributor.author | Dueñas-Roque, M. | |
| dc.contributor.author | Piscoya, A. | |
| dc.contributor.author | Fujita, R. | |
| dc.contributor.author | Sanchez, C. | |
| dc.contributor.author | Casavilca-Zambrano, S. | |
| dc.contributor.author | Jaramillo-Valverde, L. | |
| dc.contributor.author | Sullcahuaman-Allende, Y. | |
| dc.contributor.author | Iglesias-Pedraz, J.M. | |
| dc.contributor.author | Abarca-Barriga, H. | |
| dc.date.accessioned | 2025-10-31T18:46:23Z | |
| dc.date.available | 2025-10-31T18:46:23Z | |
| dc.date.issued | 2018 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12805/6248 | |
| dc.description.abstract | Peru is a pluricultural and ethnically diverse country located in middle west of South America. It is the fourth largest country (1,285,216 km2) in area in South America, bordered in the north by Ecuador and Colombia, in the south by Chile, south east by Bolivia, by Brazil in the east and by the Pacific Ocean in the west. Peru has one of the most diverse climates, geographical and ecological in the world, from tropical or subtropical dessert to glacial in highland mountains to Amazon jungle. Peru is divided into 24 geopolitical regions with a central government. According to last national census in 2017, Peruvian populations accounts for 31,237,385 inhabitants (Instituto Nacional de Estadistica e Informatica [INEI], 2017). Most of Peru's population lives in the Coastal area, with almost one third of the nation's population living in Lima, the largest city with approximately 11 million people. Rural and urban population has changed over the last 50 years due to migration waves in the 1950s from rural to urban sites mainly located in the coast causing decrease or disappearance of native communities... | en_US |
| dc.description.sponsorship | By 2011, the Peruvian National Institute of Health (Instituto Nacional de Salud del Peru) started the Peruvian Genome Project lead by Dr. Heinner Guio in collaboration with Timothy O'Connor from University of Maryland and Dr. Tarazona from Universidade Federal de Minas Gerais. Despite disparities in research cost (e.g., equipment and supplies) as compared to US (more than 2.5 times) (Sirisena & Dissanayake, 2018), a total of 280 genomes from 17 Native and 13 Mestizo populations have been analyzed (150 genomes were sequenced using whole genome sequencing and 130 using genotype array platform). This study represents the most extensive Native American sequencing project to date. The analysis shows that our Mestizo populations have 60%–70% native genes—in some geographical locations more than 80%. Most of the newly identified SNPs are mis-sense (~60,000) and come from native communities (Harris et al., 2018). Our data demonstrate a high Native ancestry component in the Peruvian population, even as compared to the results obtain in the Mexican genomic project (Belbin, Nieves‐Colón, Kenny, Moreno‐Estrada, & Gignoux, 2018). Additional studies in genomics of Peruvian populations will help us to understand these new SNPs (Elhaik et al., 2014; Sandoval et al., 2013). No doubt, these new findings from the Peruvian Genome project will enhance genetic research and medical genomics not only for Peruvians, but for Hispanics and Latinos. | |
| dc.format | application/pdf | |
| dc.language.iso | eng | |
| dc.publisher | Wiley-Blackwell | |
| dc.relation.ispartof | urn:issn:2324-9269 | |
| dc.rights | https://purl.org/coar/access_right/c_abf2 | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Genetic Insights into Human Ancestry and Diversity | en_US |
| dc.subject | Genetic Services and Health Equity in Latin America | en_US |
| dc.title | Genetics and genomics in Peru: Clinical and research perspective | en_US |
| dc.type | https://purl.org/coar/resource_type/c_dcae04bc | |
| dc.identifier.doi | https://doi.org/10.1002/mgg3.533 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#1.05.10 | |
| dc.type.other | Review | |
| dc.identifier.journal | Molecular Genetics and Genomic Medicine | |
| dc.type.version | https://purl.org/coar/version/c_970fb48d4fbd8a85 | |