Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

Towns, C.; Richer, M.; Jasaityte, S.; Stafford, E.J.; Joubert, J.; Antar, T.; Martinez-Carrasco, A.; Makarious, M.B.; Casey, B.; Vitale, D.; Levine, K.; Leonard, H.; Pantazis, C.B.; Screven, L.A.; Hernandez, D.G.; Wegel, C.E.; Solle, J.; Nalls, M.A.; Blauwendraat, C.; Singleton, A.B.; Tan, M.M.X.; Iwaki, H.; Morris, H.R.; Gatto, E.M.; Kauffman, M.; Khachatryan, S.; Tavadyan, Z.; Shepherd, C.E.; Hunter, J.; Kumar, K.; Ellis, M.; Rentería, M.E.; Koks, S.; Zimprich, A.; Schumacher-Schuh, A.F.; Rieder, C.; Awad, P.S.; Tumas, V.; Camargos, S.; Fon, E.A.; Monchi, O.; Fon, T.; Galleguillos, B.P.; Miranda, M.; Bustamante, M.L.; Olguin, P.; Chana, P.; Tang, B.; Shang, H.; Guo, J.; Chan, P.; Luo, W.; Arboleda, G.; Orozco, J.; del Rio, M.J.; Hernandez, A.; Salama, M.; Kamel, W.A.; Zewde, Y.Z.; Brice, A.; Corvol, J.-C.; Westenberger, A.; Illarionova, A.; Mollenhauer, B.; Klein, C.; Vollstedt, E.-J.; Hopfner, F.; Höglinger, G.; Madoev, H.; Trinh, J.; Junker, J.; Lohmann, K.; Lange, L.M.; Sharma, M.; Groppa, S.; Gasser, T.; Fang, Z.-H.; Akpalu, A.; Xiromerisiou, G.; Hadjigorgiou, G.; Dagklis, I.; Tarnanas, I.; Stefanis, L.; Stamelou, M.; Dadiotis, E.; Medina, A.; Chan, G.H.-F.; Ip, N.; Cheung, N.Y.-F.; Chan, P.; Zhou, X.; Kishore, A.; Kp, D.; Pal, P.; Kukkle, P.L.; Rajan, R.; Borgohain, R.; Salari, M.; Quattrone, A.; Valente, E.M.; Parnetti, L.; Avenali, M.; Schirinzi, T.; Funayama, M.; Hattori, N.; Shiraishi, T.; Karimova, A.; Kaishibayeva, G.; Shambetova, C.; Krüger, R.; Tan, A.H.; Ahmad-Annuar, A.; Norlinah, M.I.; Murad, N.A.A.; Azmin, S.; Lim, S.-Y.; Mohamed, W.; Tay, Y.W.; Martinez-Ramirez, D.; Rodriguez-Violante, M.; Reyes-Pérez, P.; Tserensodnom, B.; Ojha, R.; Anderson, T.J.; Pitcher, T.L.; Sanyaolu, A.; Okubadejo, N.; Ojo, O.; Aasly, J.O.; Pihlstrøm, L.; Tan, M.; Ur-Rehman, S.; Cornejo-Olivas, M.; Doquenia, M.L.; Rosales, R.; Vinuela, A.; Iakovenko, E.; Mubarak, B.A.; Umair, M.; Tan, E.-K.; Foo, J.N.; Amod, F.; Carr, J.; Bardien, S.; Jeon, B.; Kim, Y.J.; Cubo, E.; Alvarez, I.; Hoenicka, J.; Beyer, K.; Periñan, M.T.; Pastor, P.; El-Sadig, S.; Zweier, C.; Krack, P.; Lin, C.-H.; Wu, H.-C.; Kung, P.-J.; Wu, R.-M.; Wu, Y.; Amouri, R.; Sassi, S.B.; Başak, A.N.; Genc, G.; Çakmak, Ö.Ö.; Ertan, S.; Noyce, A.; Schrag, A.; Schapira, A.; Carroll, C.; Bale, C.; Grosset, D.; Houlden, H.; Hardy, J.; Mok, K.Y.; Rizig, M.; Wood, N.; Williams, N.; Okunoye, O.; Lewis, P.A.; Kaiyrzhanov, R.; Weil, R.; Love, S.; Stott, S.; Jasaitye, S.; Dey, S.; Obese, V.; Espay, A.; O’Grady, A.; Sobering, A.K.; Siddiqi, B.; Fiske, B.; Jonas, C.; Cruchaga, C.; Comart, C.; Wegel, C.; Hall, D.; Hernandez, D.; Shiamim, E.; Riley, E.; Faghri, F.; Serrano, G.E.; Chen, H.; Mata, I.F.; Sarmiento, I.J.K.; Williamson, J.; Kim, J.J.; Jankovic, J.; Shulman, J.; Solle, J.C.; Murphy, K.; Nuytemans, K.; Kieburtz, K.; Markopoulou, K.; Marek, K.; Levine, K.S.; Chahine, L.M.; Ibanez, L.; Screven, L.; Ruffrage, L.; Shulman, L.; Marsili, L.; Kuhl, M.; Dean, M.; Koretsky, M.; Puckelwartz, M.J.; Inca-Martinez, M.; Louie, N.; Mencacci, N.E.; Albin, R.; Alcalay, R.; Walker, R.; Bandres-Ciga, S.; Chowdhury, S.; Dumanis, S.; Lubbe, S.; Xie, T.; Foroud, T.; Beach, T.; Sherer, T.; Song, Y.; Nguyen, D.; Nguyen, T.; Atadzhanov, M.

dc.contributor.author	Towns, C.
dc.contributor.author	Richer, M.
dc.contributor.author	Jasaityte, S.
dc.contributor.author	Stafford, E.J.
dc.contributor.author	Joubert, J.
dc.contributor.author	Antar, T.
dc.contributor.author	Martinez-Carrasco, A.
dc.contributor.author	Makarious, M.B.
dc.contributor.author	Casey, B.
dc.contributor.author	Vitale, D.
dc.contributor.author	Levine, K.
dc.contributor.author	Leonard, H.
dc.contributor.author	Pantazis, C.B.
dc.contributor.author	Screven, L.A.
dc.contributor.author	Hernandez, D.G.
dc.contributor.author	Wegel, C.E.
dc.contributor.author	Solle, J.
dc.contributor.author	Nalls, M.A.
dc.contributor.author	Blauwendraat, C.
dc.contributor.author	Singleton, A.B.
dc.contributor.author	Tan, M.M.X.
dc.contributor.author	Iwaki, H.
dc.contributor.author	Morris, H.R.
dc.contributor.author	Gatto, E.M.
dc.contributor.author	Kauffman, M.
dc.contributor.author	Khachatryan, S.
dc.contributor.author	Tavadyan, Z.
dc.contributor.author	Shepherd, C.E.
dc.contributor.author	Hunter, J.
dc.contributor.author	Kumar, K.
dc.contributor.author	Ellis, M.
dc.contributor.author	Rentería, M.E.
dc.contributor.author	Koks, S.
dc.contributor.author	Zimprich, A.
dc.contributor.author	Schumacher-Schuh, A.F.
dc.contributor.author	Rieder, C.
dc.contributor.author	Awad, P.S.
dc.contributor.author	Tumas, V.
dc.contributor.author	Camargos, S.
dc.contributor.author	Fon, E.A.
dc.contributor.author	Monchi, O.
dc.contributor.author	Fon, T.
dc.contributor.author	Galleguillos, B.P.
dc.contributor.author	Miranda, M.
dc.contributor.author	Bustamante, M.L.
dc.contributor.author	Olguin, P.
dc.contributor.author	Chana, P.
dc.contributor.author	Tang, B.
dc.contributor.author	Shang, H.
dc.contributor.author	Guo, J.
dc.contributor.author	Chan, P.
dc.contributor.author	Luo, W.
dc.contributor.author	Arboleda, G.
dc.contributor.author	Orozco, J.
dc.contributor.author	del Rio, M.J.
dc.contributor.author	Hernandez, A.
dc.contributor.author	Salama, M.
dc.contributor.author	Kamel, W.A.
dc.contributor.author	Zewde, Y.Z.
dc.contributor.author	Brice, A.
dc.contributor.author	Corvol, J.-C.
dc.contributor.author	Westenberger, A.
dc.contributor.author	Illarionova, A.
dc.contributor.author	Mollenhauer, B.
dc.contributor.author	Klein, C.
dc.contributor.author	Vollstedt, E.-J.
dc.contributor.author	Hopfner, F.
dc.contributor.author	Höglinger, G.
dc.contributor.author	Madoev, H.
dc.contributor.author	Trinh, J.
dc.contributor.author	Junker, J.
dc.contributor.author	Lohmann, K.
dc.contributor.author	Lange, L.M.
dc.contributor.author	Sharma, M.
dc.contributor.author	Groppa, S.
dc.contributor.author	Gasser, T.
dc.contributor.author	Fang, Z.-H.
dc.contributor.author	Akpalu, A.
dc.contributor.author	Xiromerisiou, G.
dc.contributor.author	Hadjigorgiou, G.
dc.contributor.author	Dagklis, I.
dc.contributor.author	Tarnanas, I.
dc.contributor.author	Stefanis, L.
dc.contributor.author	Stamelou, M.
dc.contributor.author	Dadiotis, E.
dc.contributor.author	Medina, A.
dc.contributor.author	Chan, G.H.-F.
dc.contributor.author	Ip, N.
dc.contributor.author	Cheung, N.Y.-F.
dc.contributor.author	Chan, P.
dc.contributor.author	Zhou, X.
dc.contributor.author	Kishore, A.
dc.contributor.author	Kp, D.
dc.contributor.author	Pal, P.
dc.contributor.author	Kukkle, P.L.
dc.contributor.author	Rajan, R.
dc.contributor.author	Borgohain, R.
dc.contributor.author	Salari, M.
dc.contributor.author	Quattrone, A.
dc.contributor.author	Valente, E.M.
dc.contributor.author	Parnetti, L.
dc.contributor.author	Avenali, M.
dc.contributor.author	Schirinzi, T.
dc.contributor.author	Funayama, M.
dc.contributor.author	Hattori, N.
dc.contributor.author	Shiraishi, T.
dc.contributor.author	Karimova, A.
dc.contributor.author	Kaishibayeva, G.
dc.contributor.author	Shambetova, C.
dc.contributor.author	Krüger, R.
dc.contributor.author	Tan, A.H.
dc.contributor.author	Ahmad-Annuar, A.
dc.contributor.author	Norlinah, M.I.
dc.contributor.author	Murad, N.A.A.
dc.contributor.author	Azmin, S.
dc.contributor.author	Lim, S.-Y.
dc.contributor.author	Mohamed, W.
dc.contributor.author	Tay, Y.W.
dc.contributor.author	Martinez-Ramirez, D.
dc.contributor.author	Rodriguez-Violante, M.
dc.contributor.author	Reyes-Pérez, P.
dc.contributor.author	Tserensodnom, B.
dc.contributor.author	Ojha, R.
dc.contributor.author	Anderson, T.J.
dc.contributor.author	Pitcher, T.L.
dc.contributor.author	Sanyaolu, A.
dc.contributor.author	Okubadejo, N.
dc.contributor.author	Ojo, O.
dc.contributor.author	Aasly, J.O.
dc.contributor.author	Pihlstrøm, L.
dc.contributor.author	Tan, M.
dc.contributor.author	Ur-Rehman, S.
dc.contributor.author	Cornejo-Olivas, M.
dc.contributor.author	Doquenia, M.L.
dc.contributor.author	Rosales, R.
dc.contributor.author	Vinuela, A.
dc.contributor.author	Iakovenko, E.
dc.contributor.author	Mubarak, B.A.
dc.contributor.author	Umair, M.
dc.contributor.author	Tan, E.-K.
dc.contributor.author	Foo, J.N.
dc.contributor.author	Amod, F.
dc.contributor.author	Carr, J.
dc.contributor.author	Bardien, S.
dc.contributor.author	Jeon, B.
dc.contributor.author	Kim, Y.J.
dc.contributor.author	Cubo, E.
dc.contributor.author	Alvarez, I.
dc.contributor.author	Hoenicka, J.
dc.contributor.author	Beyer, K.
dc.contributor.author	Periñan, M.T.
dc.contributor.author	Pastor, P.
dc.contributor.author	El-Sadig, S.
dc.contributor.author	Zweier, C.
dc.contributor.author	Krack, P.
dc.contributor.author	Lin, C.-H.
dc.contributor.author	Wu, H.-C.
dc.contributor.author	Kung, P.-J.
dc.contributor.author	Wu, R.-M.
dc.contributor.author	Wu, Y.
dc.contributor.author	Amouri, R.
dc.contributor.author	Sassi, S.B.
dc.contributor.author	Başak, A.N.
dc.contributor.author	Genc, G.
dc.contributor.author	Çakmak, Ö.Ö.
dc.contributor.author	Ertan, S.
dc.contributor.author	Noyce, A.
dc.contributor.author	Schrag, A.
dc.contributor.author	Schapira, A.
dc.contributor.author	Carroll, C.
dc.contributor.author	Bale, C.
dc.contributor.author	Grosset, D.
dc.contributor.author	Houlden, H.
dc.contributor.author	Hardy, J.
dc.contributor.author	Mok, K.Y.
dc.contributor.author	Rizig, M.
dc.contributor.author	Wood, N.
dc.contributor.author	Williams, N.
dc.contributor.author	Okunoye, O.
dc.contributor.author	Lewis, P.A.
dc.contributor.author	Kaiyrzhanov, R.
dc.contributor.author	Weil, R.
dc.contributor.author	Love, S.
dc.contributor.author	Stott, S.
dc.contributor.author	Jasaitye, S.
dc.contributor.author	Dey, S.
dc.contributor.author	Obese, V.
dc.contributor.author	Espay, A.
dc.contributor.author	O’Grady, A.
dc.contributor.author	Sobering, A.K.
dc.contributor.author	Siddiqi, B.
dc.contributor.author	Fiske, B.
dc.contributor.author	Jonas, C.
dc.contributor.author	Cruchaga, C.
dc.contributor.author	Comart, C.
dc.contributor.author	Wegel, C.
dc.contributor.author	Hall, D.
dc.contributor.author	Hernandez, D.
dc.contributor.author	Shiamim, E.
dc.contributor.author	Riley, E.
dc.contributor.author	Faghri, F.
dc.contributor.author	Serrano, G.E.
dc.contributor.author	Chen, H.
dc.contributor.author	Mata, I.F.
dc.contributor.author	Sarmiento, I.J.K.
dc.contributor.author	Williamson, J.
dc.contributor.author	Kim, J.J.
dc.contributor.author	Jankovic, J.
dc.contributor.author	Shulman, J.
dc.contributor.author	Solle, J.C.
dc.contributor.author	Murphy, K.
dc.contributor.author	Nuytemans, K.
dc.contributor.author	Kieburtz, K.
dc.contributor.author	Markopoulou, K.
dc.contributor.author	Marek, K.
dc.contributor.author	Levine, K.S.
dc.contributor.author	Chahine, L.M.
dc.contributor.author	Ibanez, L.
dc.contributor.author	Screven, L.
dc.contributor.author	Ruffrage, L.
dc.contributor.author	Shulman, L.
dc.contributor.author	Marsili, L.
dc.contributor.author	Kuhl, M.
dc.contributor.author	Dean, M.
dc.contributor.author	Koretsky, M.
dc.contributor.author	Puckelwartz, M.J.
dc.contributor.author	Inca-Martinez, M.
dc.contributor.author	Louie, N.
dc.contributor.author	Mencacci, N.E.
dc.contributor.author	Albin, R.
dc.contributor.author	Alcalay, R.
dc.contributor.author	Walker, R.
dc.contributor.author	Bandres-Ciga, S.
dc.contributor.author	Chowdhury, S.
dc.contributor.author	Dumanis, S.
dc.contributor.author	Lubbe, S.
dc.contributor.author	Xie, T.
dc.contributor.author	Foroud, T.
dc.contributor.author	Beach, T.
dc.contributor.author	Sherer, T.
dc.contributor.author	Song, Y.
dc.contributor.author	Nguyen, D.
dc.contributor.author	Nguyen, T.
dc.contributor.author	Atadzhanov, M.
dc.date.accessioned	2025-10-31T18:37:00Z
dc.date.available	2025-10-31T18:37:00Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/20.500.12805/5470
dc.description.abstract	The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.	en_US
dc.description.sponsorship	Funding text 1: This research is supported by the Aligning Science Across Parkinson’s Initiative, the Intramural Research Program, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949, and the Michael J. Fox Foundation for Parkinson’s Research. Data used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org .; Funding text 2: A.B.S. and C.B. are supported by the Intramural Research Program of the National Institute on Aging and have received grant support from the Michael J. Fox Foundation for Parkinson’s Research and the Aligning Science Across Parkinson’s Initiative. A.B.S. has received royalty payments related to a diagnostic for stroke. A.B.S. is an editor for npj Parkinson’s Disease. A.B.S. was not involved in the journal’s review of, or decisions related to, this manuscript. H.L., H.I., D.V., K.L., and M.A.N. are consultants employed by Data Tecnica International. Data Tecnica is engaged in a consulting agreement with the US National Institutes of Health. H.R.M. is employed by UCL. In the last 24 months, he reports paid consultancy from Biogen, Biohaven, Lundbeck; lecture fees/honoraria from Wellcome Trust, Movement Disorders Society; Research Grants from Parkinson’s UK, Cure Parkinson’s Trust, PSP Association, CBD Solutions, Drake Foundation, Medical Research Council, Michael J. Fox Foundation. H.R.M. is also a co-applicant on a patent application related to C9ORF72—Method for diagnosing a neurodegenerative disease (PCT/GB2012/052140). BC and JS are employed by the Michael J. Fox Foundation for Parkinson’s Research. All other authors declare no financial or non-financial competing interests.
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Research
dc.relation.ispartof	urn:issn:2373-8057
dc.rights	https://purl.org/coar/access_right/c_abf2
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject	Parkinson's Disease: Gait, Cognition, and Quality of Life	en_US
dc.subject	Parkinson's Disease Subtypes and Progression	en_US
dc.title	Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)	en_US
dc.type	https://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.doi	https://doi.org/10.1038/s41531-023-00533-w
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.00.00
dc.type.other	Research article
dc.identifier.journal	npj Parkinson's Disease
dc.type.version	https://purl.org/coar/version/c_970fb48d4fbd8a85

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