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dc.contributor.authorÀlvarez, G.
dc.contributor.authorArredondo, A.
dc.contributor.authorIsabal, S.
dc.contributor.authorTeughels, W.
dc.contributor.authorLaleman, I.
dc.contributor.authorContreras, M.J.
dc.contributor.authorIsbej, L.
dc.contributor.authorHuapaya, E.
dc.contributor.authorMendoza, G.
dc.contributor.authorMor, C.
dc.contributor.authorNart, J.
dc.contributor.authorBlanc, V.
dc.contributor.authorLeón, R.
dc.date.accessioned2025-10-31T18:36:03Z
dc.date.available2025-10-31T18:36:03Z
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/20.500.12805/5364
dc.description.abstractAim: Our aim was to compare the prevalence and load of nine pathobionts in subgingival samples of healthy individuals and periodontitis patients from four different countries. Methods: Five hundred and seven subgingival biofilm samples were collected from healthy subjects and periodontitis patients in Belgium, Chile, Peru and Spain. The prevalence and load of Eubacterium brachy, Filifactor alocis, Fretibacterium fastidiosum, Porphyromonas endodontalis, Porphyromonas gingivalis, Selenomonas sputigena, Treponema denticola, Tannerella forsythia and Treponema socranskii were measured by quantitative PCR. Results: The association with periodontitis of all species, except for T. socranskii, was confirmed in all countries but Peru, where only P. endodontalis, P. gingivalis and T. denticola were found to be significantly associated. Moreover, most species showed higher loads at greater CAL and PPD, but not where there was BOP. Through Principal Component Analysis, samples showed clearly different distributions by diagnosis, despite observing a smaller separation in Peruvian samples. Conclusions: Unlike prevalence, relative load was found to be a reliable variable to discriminate the association of the species with periodontitis. Based on this, F. alocis, P. endodontalis, P. gingivalis, T. denticola and T. forsythia may be biomarkers of disease in Belgium, Chile and Spain, due to their significantly higher abundance in periodontitis patients.en_US
dc.description.sponsorshipThis study was funded by the company Dentaid S.L. We would like to thank Mrs Ann Bangle for her help in reviewing the language.
dc.formatapplication/pdf
dc.language.isoeng
dc.publisherTaylor and Francis
dc.relation.ispartofurn:issn:2000-2297
dc.rightshttps://purl.org/coar/access_right/c_abf2
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectFluoride and Oral Health in Childrenen_US
dc.subjectMicrobiome Dynamics in Oral Health and Diseaseen_US
dc.titleAssociation of nine pathobionts with periodontitis in four South American and European countriesen_US
dc.typehttps://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.doihttps://doi.org/10.1080/20002297.2023.2188630
dc.subject.ocdehttps://purl.org/pe-repo/ocde/ford#3.02.14
dc.type.otherResearch article
dc.identifier.journalJournal of Oral Microbiology
dc.type.versionhttps://purl.org/coar/version/c_970fb48d4fbd8a85


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