New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou

Fuchino, H.; Kiuchi, F.; Yamanaka, A.; Obu, A.; Wada, H.; Mori-Yasumoto, K.; Kawahara, N.; Flores, D.; Palacios, O.; Sekita, S.; Satake, M.

dc.contributor.author	Fuchino, H.
dc.contributor.author	Kiuchi, F.
dc.contributor.author	Yamanaka, A.
dc.contributor.author	Obu, A.
dc.contributor.author	Wada, H.
dc.contributor.author	Mori-Yasumoto, K.
dc.contributor.author	Kawahara, N.
dc.contributor.author	Flores, D.
dc.contributor.author	Palacios, O.
dc.contributor.author	Sekita, S.
dc.contributor.author	Satake, M.
dc.date.accessioned	2025-10-31T18:33:41Z
dc.date.available	2025-10-31T18:33:41Z
dc.date.issued	2013
dc.identifier.uri	https://hdl.handle.net/20.500.12805/4990
dc.description.abstract	Two new stilbenes, 1 and 2, were isolated as leishmanicidal constituents from the methanolic extract of Lonchocarpus nicou leaves and stem, together with five known stilbenes and rotenoids. Their chemical structures were determined by spectral methods. Among them, the cis stilbene-type compounds 1 and 4 showed potent leishmanicidal activity (IC<inf>50</inf>: 5.5, 3.9μg/mL), while the trans stilbene-type compounds 2 and 5, and rotenoids 6 and 7, showed moderate activities (IC<inf>50</inf>: 9.9, 12.8, 22.6, 19.6μg/mL, respectively).	en_US
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Pharmaceutical Society of Japan
dc.relation.ispartof	urn:issn:0009-2363
dc.rights	https://purl.org/coar/access_right/c_abf2
dc.rights.uri	https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject	Medicinal Plant Extracts for Pain Management	en_US
dc.subject	Rotenoids and Their Role in Cancer Therapy	en_US
dc.title	New leishmanicidal stilbenes from a peruvian folk medicine, Lonchocarpus nicou	en_US
dc.type	https://purl.org/coar/resource_type/c_2df8fbb1
dc.identifier.doi	https://doi.org/10.1248/cpb.c13-00385
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.10
dc.type.other	Research article
dc.identifier.journal	Chemical and Pharmaceutical Bulletin
dc.type.version	https://purl.org/coar/version/c_970fb48d4fbd8a85

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